Opportunity Information: Apply for FOR FD 20 001
This grant opportunity from the U.S. Department of Health and Human Services, Food and Drug Administration (FDA) centers on creating a rigorous, evidence-based clinical practice guideline (CPG) for managing dental pain, covering both surgical and non-surgical scenarios. The effort stems from the SUPPORT Act, a federal law enacted in October 2018 to address the opioid crisis. Section 3002 of that law directs the FDA Commissioner to develop indication-specific, evidence-based opioid analgesic prescribing guidelines for acute pain in areas where such guidance is missing. In response, FDA worked with the National Academies of Sciences, Engineering, and Medicine (NASEM) to outline a broader framework for guideline development. A NASEM consensus report released in December 2019 highlighted specific procedures and medical conditions where more research and guideline development were needed, and it identified dental pain and common dental surgeries as top priorities.
The rationale for focusing on dentistry is tied to both public health impact and prescribing patterns. Dental procedures such as third molar (wisdom tooth) extraction are extremely common, and they frequently involve adolescents and young adults, a population that can be especially vulnerable to first exposures to opioid medications. The NASEM report pointed to existing evidence showing that nonopioid pain management strategies can be highly effective for dental pain, particularly after routine dental surgeries. At the same time, dental pain has been documented as one of the leading reasons adolescents and young adults receive opioid prescriptions in emergency department settings. Taken together, those factors create a strong case for a clear, widely adopted guideline that supports effective pain relief while reducing unnecessary opioid exposure.
FDA’s proposed funding is not limited to writing a guideline document. The scope explicitly includes development, dissemination, implementation, and evaluation. In practical terms, this means the funded project is expected to do more than convene experts and review the literature; it also needs a real-world plan to get the guideline into clinical workflows and measure whether it changes prescribing and patient outcomes. NASEM specifically recommended that organizations producing evidence-based opioid-related acute pain guidelines also establish processes to disseminate the guideline, support implementation, and monitor uptake and impact. This opportunity aligns with that recommendation by making dissemination and evaluation core deliverables rather than optional add-ons.
The award is structured as a cooperative agreement, which typically signals substantial federal involvement during the project period, such as ongoing coordination, shared decision-making on key milestones, and alignment with FDA’s broader guideline framework. The opportunity anticipates a single award (ExpectedAwards: 1), suggesting FDA is looking for one lead organization or consortium to coordinate the full guideline lifecycle from evidence synthesis through adoption and impact assessment.
Eligibility is broad and includes many types of applicants that could credibly lead a national guideline effort. Eligible entities include state, county, and local governments; public and private institutions of higher education; federally recognized tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status; for-profit organizations (including entities other than small businesses); small businesses; and other applicants as clarified in the funding notice. The funding opportunity is listed under CFDA 93.103 and the activity category is labeled Agriculture, Consumer Protection, Food and Nutrition, reflecting FDA’s cataloging conventions rather than dentistry specifically. The funding opportunity number is FOR FD 20 001, and it was created May 25, 2021.
Overall, the grant is aimed at producing a trustworthy, evidence-driven dental pain guideline that helps clinicians choose effective treatments while minimizing avoidable opioid prescribing. Just as importantly, it is designed to ensure the guideline does not sit on a shelf: the funded work is expected to actively drive awareness and use across dental and related care settings and to generate evidence on whether the guideline meaningfully improves prescribing practices and patient care.Apply for FOR FD 20 001
- The Department of Health and Human Services, Food and Drug Administration in the agriculture, consumer protection, food and nutrition sector is offering a public funding opportunity titled "An evidence-based clinical practice guideline for dental pain (surgical and non-surgical)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.103.
- This funding opportunity was created on May 25, 2021.
- Applicants must submit their applications by Archiving forecast. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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