The NHGRI Genomic Data Science Analysis, Visualization, and Informatics Lab-space Clinical Resource (ACR) (U24 Clinical Trial Not Allowed) | RFA HG 22 021

Opportunity Information: Apply for RFA HG 22 021

The National Institutes of Health (NIH), through the National Human Genome Research Institute (NHGRI), released this discretionary funding opportunity (RFA HG 22 021) to support a major shared infrastructure effort in clinical genomics: the creation and ongoing operation of the AnVIL Clinical Resource (ACR). The award mechanism is a U24 cooperative agreement, which means the funded group would not just receive funds and work independently, but would coordinate closely with NHGRI with substantial program involvement. The FOA is explicitly labeled "Clinical Trial Not Allowed," indicating the work is intended to build and run resources that enable research rather than to conduct interventional clinical trials.

At its core, the opportunity is about building a suite of genomic-based clinical tools and services directly within AnVIL, the NHGRI Data Science Analysis, Visualization, and Informatics Lab-space. AnVIL is described as a scalable, interoperable, cloud-based platform designed to make it easier for both basic and clinical genomics communities to access large datasets, share data responsibly, and perform computational analyses without needing extensive local computing infrastructure. In practical terms, this FOA aims to extend AnVIL so it better supports clinical genomic research use cases, including the kinds of analysis, visualization, and informatics functions that clinicians and clinical researchers rely on when working with genomic and genomic-related data. The emphasis on "development, implementation, and maintenance" signals that NHGRI is looking for an end-to-end capability: building the resource, deploying it in a usable form, keeping it stable, and sustaining it as an operational clinical research support environment rather than treating it as a short-term software project.

The ACR concept is framed as a "clinical resource" embedded in AnVIL, suggesting a curated, dependable set of capabilities that can be used broadly by the community. While the FOA summary does not list specific modules or features, the stated purpose implies tools and services that help translate genomic data science into clinical research workflows, such as standardized processing, analysis pipelines, interactive visualization, and informatics components that help organize, interpret, and work with clinically relevant genomic information in a secure and shareable cloud setting. The broader rationale is to "democratize" computing and data access across large datasets by leveraging cloud infrastructure, reducing barriers for institutions that might not have the same level of on-premises computational resources.

Eligibility is broad and includes many typical NIH applicant categories: state, county, city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations that are not federally recognized tribal governments; public housing authorities/Indian housing authorities; nonprofits (both 501(c)(3) and non-501(c)(3)); for-profit organizations (other than small businesses); small businesses; and other eligible entities. In addition, the FOA explicitly highlights further eligible applicants such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISISs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, U.S. territories or possessions, eligible federal agencies, and even non-U.S. entities (foreign organizations). Taken together, that list reflects an intent to attract a diverse set of capable organizations, including institutions that serve underrepresented communities and organizations outside the United States that can contribute meaningfully to the resource.

Administratively, the FOA falls under the NIH health activity category and is associated with CFDA number 93.172. The opportunity was created on 2022-09-16, with an original closing date of 2022-12-02. The excerpt provided does not specify an award ceiling or the expected number of awards, but the structure and scope strongly suggest a substantial, centralized resource award designed to support a community-facing platform capability rather than a typical single-lab research project.

In summary, this funding opportunity is aimed at strengthening the clinical genomics ecosystem on AnVIL by funding a team (or consortium) to build and operate the AnVIL Clinical Resource: a set of cloud-based clinical genomics tools and services that expand AnVIL's utility for clinical genomic research, improve interoperability and scalability, and lower barriers to analyzing and sharing large genomic datasets. The work is infrastructure- and service-oriented, carried out in partnership with NHGRI under a cooperative agreement, and intentionally positioned to benefit a wide and diverse research community without supporting clinical trials.

• The National Institutes of Health in the health sector is offering a public funding opportunity titled "The NHGRI Genomic Data Science Analysis, Visualization, and Informatics Lab-space Clinical Resource (ACR) (U24 Clinical Trial Not Allowed)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.172.
• This funding opportunity was created on 2022-09-16.
• Applicants must submit their applications by 2022-12-02. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for RFA HG 22 021

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